Hybrid vectors based on adeno-associated virus serotypes 2 and 5 for muscle-directed gene transfer.

نویسندگان

  • M Hildinger
  • A Auricchio
  • G Gao
  • L Wang
  • N Chirmule
  • J M Wilson
چکیده

Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directed gene transfer (called AAV2/5). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly, we saw no immunologic evidence of previous exposure to AAV5 capsids in a large population of healthy human subjects.

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عنوان ژورنال:
  • Journal of virology

دوره 75 13  شماره 

صفحات  -

تاریخ انتشار 2001